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Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Signal transduction converts a stimulus to a receptor, and ends with a change in cell function.
However, it is not clear whether this represents loss of circulating specific cells and/or change in cell function.
Histological abnormalities are more often observed in older individuals [ 6], although the relationship with ageing and the apparent change in cell function is not clear.
These terms included proteins involved in the cytoskeletal structure, proteins involved in cell adhesion, and receptor proteins that combine with neurotransmitters or other signaling molecules to cause a change in cell function.
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Upregulation of a conserved transcription initiation factor TFIIH core subunit, GTFIIH1 (p62), as well as the downregulation of SLC38A2 could reflect a global change in cell functioning.
Calmodulin (CaM) is the Ca2+ receptor that orchestrates Ca2+-initiated signal transduction cascades leading to changes in cell function.
It should be kept in mind that skin fibroblasts are not the primary cell type that is affected in LOAD and that changes in cell function are most likely partly cell-specific.
DNA damage is a ubiquitous threat to genomic stability, and depending on the type and extent of the damage, can lead to widespread changes in cell function as well as cell death.
To recapitulate this complex environment in vitro, dynamic polymer-based biomaterials have emerged as powerful tools to probe and direct active changes in cell function.
Thus, prolonged exposure to ET-743 may cause changes in cell function through cytoskeleton rearrangement and/or modulation of collagen levels.
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