6. Amin, F.M., Hougaard, A., Magon, S., Asghar, M.S., Ahmad, N.N., Rostrup, E., Sprenger, T., Ashina, M. Change in brain network connectivity during PACAP38-induced migraine attacks: A resting-state functional MRI study.
Based on findings of consistent age-related differences in activation patterns and functional network topology across memory encoding and recognition tasks, Grady et al. and Wang et al. argued that age-related changes in brain network organization derive from a common, domain-general factor [26], [39].
51 Extensive changes in brain networks are observed when comparing CAE to healthy controls, particularly a marked relative increase in covariance of the medial frontal lobe bilaterally, and a relative decrease in covariance in the occipital and parietal lobes.
Future research, however, ought to assess whether and how focal thalamic damage can trigger maladaptive functional reorganization changes in brain networks, which may further account for the impaired WM biasing of attention reported here.
Longitudinal studies of abstinent alcoholics at rest and during task performance would definitively establish whether plastic changes in the synchronous activity in brain networks reflects a crucial brain mechanism underlying the behavior changes in alcoholics that result in extended abstinence.
The theory that some treatment methods were able to change the functional connectivity of nodes in brain networks had been confirmed in recent researches [48,49].
Aging is accompanied by declines in executive control abilities and changes in underlying brain network architecture.
Furthermore the study is limited to a network-based statistical analysis of the frontal-parietal-striatal network and was therefore unable to address the selective vulnerability of rich club brain regions or global changes in the brain network as we have done in this work.
To answer these questions, one could isolate an attention-related activity in someone's behavioral repertoire (e.g., how well they do in attending to something) and connect that to changes in their brain networks—exactly the approach that some labs have taken.
This study was, however, pseudo-longitudinal, and thus further longitudinal analysis is required to confirm the progression in structural brain network change over time in Huntington's disease.
We show highly connected brain regions, with high network traffic, are most susceptible to structural connectivity loss in Huntington's disease, which results in clinically relevant brain network changes of increased segregation in the premanifest stage and loss of integration in the manifest stage.
