As chromatin-modifying mechanisms can change gene expression without changing the DNA sequence of regulatory elements driving gene expression, chromatin modification is an epigenetic mechanism of gene regulation (the prefix epi- meaning on, upon, or above).
Nanotechnology, the science of working with particles that are one billionth of a meter, is enabling scientists to change gene expression on the cellular level, potentially curing a host of diseases.
The 2−ΔΔCTmethod was used to analyze the fold change gene expression over the control (Lival and Schmittgen 2001).
Ketone bodies, metabolites that accumulate during fasting, change gene expression by inhibiting histone deacetylases.
It was concluded that different dietary ingredients could change gene expression of hepatic gluconeogenesis pathway, especially PEPCK and G6P.
For each of the 35 genes, we determined a range in HC fold change gene expression, defined by the HC mean ± 1 standard deviation (SD).
Environmental factors, like malnutrition and stress, can change gene expression.
The essence of the fetal programming idea is that impacts on local fetal cellular environments can change gene expression during the developmental construction of tissues and organs, and these changes can result in long-range consequences for the function of those tissues and organs during childhood and adulthood.
In brief, heat, other proteotoxic stresses, and diverse other signals change gene expression dramatically.
We then performed hierarchical clustering to demonstrate whether cellular fixation alone could change gene expression.
Epigenetic mechanisms, including DNA methylation and histone modifications, change gene expression without alteration of the DNA sequence itself.
