Exact(2)
Currently, there is a movement from change endpoints to endpoints with absolute values.
In contrast to change endpoints, when using absolute measures there is no need to choose cut-off points, and the difference between two drugs or between a drug and placebo can readily be interpreted in terms of the endpoint measure.
Similar(58)
The press release issued last week said the study failed to show a benefit on the changed endpoint as well.
"We never made a recommendation to change any endpoints.
The relationship between baseline and change in endpoints, and study size versus year of publication, was assessed using linear regression.
The relationship between year of publication and baseline and change in endpoints was assessed using Spearman regression.
Table 2 presents changes on the eight primary and secondary outcome measures from baseline to endpoint, and self-reported ratings of change at endpoint.
We used these established changes as endpoints for a study designed to determine if cigarette smoke induces evidence of changes associated with AMD.
Model predictive abilities changed across endpoints.
But we had no power to change the endpoint.
The same day, Merck and Schering said they would not change the endpoint after all.
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