Sentence examples for change chromatin structure from inspiring English sources

By comparison, small molecule Hdac inhibitors have short half-lives in serum and might only temporally change chromatin structure and gene expression in relatively short-term cell culture assays.

These histone modifications may serve as a binding platform for non-histone proteins, whose activities change chromatin structure and function.

As such, methylation marks change chromatin structure by different mechanisms, involving the recruitment or inhibition of recruitment of distinct enzymatic complexes [ 25, 26].

To obtain a comprehensive view of how VPA treatment might change chromatin structure, we constructed DHSS libraries from VPA- (200 mg/kg, i.p).

Generally, certain histone modifications such as acetylation or phosphorylation are thought to change chromatin structure by altering the net positive charge of the histone proteins, thereby rendering the underlying DNA sequence information more accessible [24].

Some histone modifications act in cis to change chromatin structure directly, whereas others act in trans to affect the recruitment of a protein complex that regulates gene expression [ 36].

Besides covalent histone modifications, another important mechanism that changes chromatin structure is accomplished by a series of ATP-dependent chromatin remodelling complexes.

Because histones are still present in spores, the transient DSBs do not require a major change in chromatin structure.

A second possibility is the change in chromatin structure.

In the absence of telomerase, telomere shortening occurs and eventually causes a change in chromatin structure.

We found a few exceptions that despite their subtelomeric locations showed minimal change in chromatin structure.