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After normalizing for this change, cell lines with Fringe expression appear to have stronger cis interactions.
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These EMT-like changes include a spectrum of morphological changes between cell lines ranging from a more flattened and less cohesive morphology to the dramatic scattered morphology seen in Colony 29.
Recent research suggests that cigarette smoke and antipsychotic treatment may lead to gene-silencing effects through DNA methylation changes [ 58- 60] which could lead to long-term changes in cell lines derived from smokers.
The fact that the expression changes seen in the primary tumor sample after treatment with 17AAG resembled the changes in cell lines, suggests that this set of genes would constitute a robust signature of response in breast cancer.
Finally, PTM levels were Z-score normalized to emphasize relative changes across cell lines.
We apply this method to microarray data measuring gene expression changes in cell lines transfected with certain miRNAs or anti-miRNAs (miRNA-specific inhibitors).
To validate this method, we apply it to the microarray data sets that measure gene expression changes in cell lines after transfection or inhibition of several specific miRNAs.
In this study, we take advantage of the signaling changes in cell lines lacking the TSC1-TSC2 complex to determine whether mTORC1 signaling downstream of Akt plays an important role in adipogenesis.
Fold changes between cell lines are indicated.
Despite these changes, both cell lines sustained relatively unaltered mitochondrial respiration.
This is in contrast to CG poor regions that experience extensive methylations changes across cell lines (Stadler et al., 2011).
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