Sentence examples for change and activation from inspiring English sources

It is conceivable that the tail itself or other unknown associated molecules may help to facilitate the conformational change and activation of GPCR interacting heterotrimeric G proteins upon ligand stimulation [49].

Given the fact that the activation of TLR9 involves ligand-induced conformational changes to the TLR9 homodimers, our results suggests that TLR9 conformational change and activation was induced by CpG DNA and not by non CpG DNA because of a significant difference in the dissociation constant values obtained from our in vivo single molecule experiments.

The ADP receptor binds to the G protein coupled receptors P2Y12 (Gi/adenylyl cyclase pathway) and P2Y1 (Gq/phospholipase C/Ca2 pathway), initiating platelet shape change and activation.

Recent high-resolution crystal structures of Parkin lacking the Ubl domain suggest that Parkin is autoinhibited; however, the studies do not shed any light on the mechanism of how Ser phosphorylation triggers conformational change and activation of Parkin [ 14– 16].

Activation of Pins is achieved by the binding of the heterotrimeric G protein Gαi to the GoLoco repeats, resulting in a conformational change and activation of the Pins protein [ 33].

We hypothesize that phosphorylation of Ipr1 (induced in our screen by PMA) may mask its protease cleavage sites by causing conformational change and activation-induced protein complex formation (as shown previously)21, enabling GFP-Ipr1 translocation to the nucleus, where it dynamically associates with target chromatin via its SAND domain and nuclear matrix via its Sp100 domain.

Ashok, I. & Sheeladevi, R. Neurobehavioral changes and activation of neurodegenerative apoptosis on long-term consumption of aspartame in the rat brain.

Taken together, our data suggest that localized proteotoxicity induces a response across the entire cell, one that includes metabolic changes and activation of folding maintenance machinery in multiple compartments.

We experimentally validated miR-34a, miR-107, and miR-212-3p miR-212-3p miR-212-3pmatargetingeler Chd1 and further demofsthete that chromatinkdown mimics high-fat diet and aging-induced gene expremodelerhanges and aChd1andon ofurtherposons.

Subcutaneous injections of silica have been reported to induce sclerodermatous skin changes and activation of skin fibroblasts [23].

A variety of metabolic and endocrine changes and activation of catabolic pathways account for some of the weight loss [ 3].