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While we conclude that hNPC secreting GDNF may represent a viable source of cells for protecting dying motor neurons, further animal studies are clearly needed to slow the loss of muscle innervation and thus increase the chances of functional recovery following transplantation.
In the light of the study findings, primary care physicians should seek for an effective management of these PPS, and closely monitor the patients' improvement, so in this way the chances of functional recovery would be increased.
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They allow penetration of the tendon sheath and surroundings by the injected material with lower chance of functional outcome.
Complete paralysis for >48 h without significant concern for an ascending lesion (surgical risks likely to outweigh the chance of functional recovery).
The primary factors involved in the selection of these regions included the lack of potential promoter sequences and also sufficient distance from nearby genes, thus decreasing the chance of functional disruption by the foreign gene insertion.
Early rehabilitation should also prevent disuse syndrome and related conditions such as pneumonia and decubitus ulcers, which may also lead to better chance of functional recovery.
Because the age (sequence divergence) of duplicate genes may influence the chance of functional compensation, we computed the p-distance (proportion of amino acid differences) and the synonymous distance (Ks) between a knockout gene and its closest paralog.
Our results clearly show that the normalized ratio increases for higher sequence identity intervals as well as higher levels of shared GO Indices, highlighting the higher chance of functional conservation over randomly chosen pairs for these groups.
We excluded those who were hospitalised for more than 180 days, who had intracranial haemorrhages, and who received a surgical operation since these patients were likely to have heterogeneous conditions that may have confounded their chance of functional recovery and mortality.
The combinatorial materials sciences approach has dramatically increased the probability of chance discoveries of functional materials.
It might be true that highly pleiotropic genes would have higher chances of developing functional overlaps among themselves in the fixed functional space of a cellular system.
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