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Two non-exclusive mechanisms may be responsible: inbreeding depression and chance linkage between a marker and an immune-related gene experiencing balancing selection (Hansson & Westerberg 2002; Kaeuffer et al. 2008).
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In order to validate that our findings were not due to chance or linkage disequilibrium (LD) with a nearby functional variant, we used a knockout mouse model to determine if we could replicate our results in an experimental setting.
On the one hand, previous HIV testing and CD4 testing may imply greater contact with the health service and therefore increased chances for linkage to further care (e.g. viral load testing and ART initiation).
Furthermore, the one-step (MES) method allows better carboxyl activation and a higher chance of extra linkages or cross-linkage, but it can also cause excessive cross-linkages from the side changes of the peptides, which can lower the efficacy of the vaccine peptides.
These are groups for which changes occur more frequently in the same branches than expected by chance, but the linkage is not as strong as in rRNA.
An alternative explanation for the link between ovary size and foraging behaviour is that genes for ovarian development and foraging are inherited together because of genetic linkage or chance gene associations in the selected and natural populations.
Clusters that include highly expressed genes are not more likely to be conserved than expected by chance [ 27], and linkage between highly expressed genes may in fact be deleterious [ 28].
Moreover, my participation would have given me the chance to learn the linkages of girls' empowerment to that of sustainable development, and to unlock and discover the potential within me...
The only permanent way to reduce that sum was to have permanent peace, and one guesses that the chance of such a utopian linkage helped move Coolidge to support, with whatever reluctance and delay, an international pact outlawing war, the brainchild of his Secretary of State, Frank Kellogg.
Remotely, there is even a chance that another gene in linkage disequilibrium with the variant accounts for the observed effects.
The updated QTL model had better prediction accuracy than the original model, and the updated GWAS provided substantially higher marker density, which is expected to provide a better chance of identifying variants in linkage disequilibrium with causal variants.
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CEO of Professional Science Editing for Scientists @ prosciediting.com