However, registering this diversity and understanding its possible consequence is challenging, because variation in chromatin marks has complex properties.
Mechanistic insights have been challenging since variation within this locus is complex and biological roles of the factor H-related proteins, unlike factor H, are incompletely understood.
This event is the only time the Ultimate X Challenge variation of the Ultimate X match has been used.
Neuronal processing is significantly challenged by variation in temperature due to the changes in chemical and physical processes.
Involvement of the mdr1 gene in chloroquine resistance has been challenged, but variation at codon 86 of this gene modulates resistance to chloroquine (10 ).
Proper warfarin dosing is challenging due to variation in VKORC1 and CYP2C9 genes (Table 3), which impact the clinical efficacy of the medication [46 49].
Interpretation of such comparisons is challenging because of variation in influenza activity from season to season.
A direct comparison of the level of macrophage activation is however challenging considering the variation in cell cultures and isolates used in the various studies.
The estimation of treatment differences in terms of the reduction in rate of exacerbations was challenging due to variation in the definitions used across the randomized controlled trials.
Accurate transfer of retention patterns in temperature-programmed gas chromatography is challenging because minor variations in column properties and experimental conditions may have significant impact on the elution patterns.
