Understanding if variant PRC1 complexes can drive this process at natural target sites is challenging, as variant PRC1 complex targeting mechanisms remain poorly defined.
Compounded by both allelic and locus heterogeneity 82, the sheer number of low-frequency, rare and private variants will make identification of the causal variants challenging.
In addition, lambs infected with variant 1 showed no clinical or haematological reactions when challenged with variant 2 on days 7 and 42, and only one day with mild fever (T<41.0°C) was observed when challenged on day 84.
However, lambs primary infected with variant 2 reacted with fever (one day, T<41.0°C) and neutropenia when challenged with variant 1 on day 7, being fully susceptible to A. phagocytophilum var 1 infection when challenged on day 42 and 84 (data not shown).
This makes comparison and interpretation of cognitive impairment across patients challenging when different variants of the ADAS-Cog are used.
Many genetic alterations are relevant to the accurate classification of leukemia and they sometimes can generate multiple transcript variants challenging to detect with sequence-specific molecular methods.
In a large-scale GWAS, it is challenging to identify variants with moderate to weak effect sizes because of the need to control for the problem of simultaneously testing hundreds of thousands of SNP markers (i.e., multiplicity).
Information on splice variants is, therefore, crucial for understanding gene functioning, but reliable and accurate determination of splice variants is challenging due to the small length of HiSeq reads that were analysed in this study.
However, interpretation of these novel SHANK3 variants is challenging.
Therefore, the distinction of its driver mutations from constitutional variants is challenging.
