The phrase "challenging trial" is correct and usable in written English.
You can use it to describe a difficult test, task, or experience. For example, "Samantha faced a challenging trial when she had to prove her innocence in court."
Our study provided information to help ensure that a challenging trial was patient centred in its design.
A consequence of establishing such a successful trials network is the opportunity to develop more challenging trial designs to address more complex issues.
This has been a challenging trial to design, however the design is applicable to many other treatment strategies using different drugs and in different disease areas.
The staff of the Department of Geriatrics and the Trauma Unit, Department of Orthopaedic Surgery and also the Emergency Department are highly acknowledged for more than 2 1/2 year of extensive participation in a comprehensive and challenging trial both regarding work-load, logistics and professional attitude.
Where deferred consent is being considered for a potentially challenging trial (eg, trials involving change in clinical practice such as a new or novel intervention), the views of parents, children and practitioners should be systematically sought through substantive research at the pretrial (eg, feasibility or pilot) stage to inform the trial design, recruitment and approach to consent.
Findings from research to explore the views of parents approached for deferred consent when EcLiPSE recruitment begins will be incorporated into trial information and practitioner training as part of an iterative process 40 41 to inform trial recruitment and approaches to consent in this challenging trial.
It will be crucial to follow-up these inhibition results in phase 2a challenge trials and efficacy studies in field trials to validate these in vitro inhibition assays as correlates for protection.
The study design was a blinded, randomized challenge trial.
Aloe had no significant effect (p > 0.05) on the survival of the fish when compared to the control; no mortality was recorded in challenge trial.
Near the end of the disease challenge trial when there were only a few prawns remaining in the tanks, hourly observations were made to ensure that only freshly dead prawns were used.
It was a rare kind of study: a "challenge" trial in which hexamethonium, a drug not currently approved by the Food and Drug Administration FDAA), was used to induce asthma-like symptoms in healthy subjects.
