Sentence examples for challenging to target from inspiring English sources

It has been challenging to target maladaptive generalized memories without affecting adaptive memories.

From a strictly traditional PPC perspective, it is challenging to target a campaign at the persona level, unless you can have granular control across content, video, social, and paid channels.

Moreover, the ability to potentially inhibit CK1ε using available inhibitors would facilitate downregulation of Wnt/β-catenin signaling in human tumors, which has proven challenging to target pharmacologically.

However, transcription factors such as MYC are challenging to target directly and clinically-effective pharmaceutical agents targeting MYC are not yet available [ 17, 18].

Since CLU is challenging to target with traditional small-molecule inhibitors, the ASO drug OGX-011 (custirsen) was developed to instead inhibit mRNA translation.

Frail and older individuals, unlike groups with a single main diagnosis, are a diffuse group that are challenging to target in a literature search.

With local authorities facing major cutbacks, the challenge to target resources effectively is immense.

The couple only switched course after a federal judge invited them to expand their challenge to target the state constitution's ban on same-sex marriage.

They discuss a challenge to target the most relevant pathophysiology to treat these symptoms.

It is, therefore, a big challenge to target these treatment-resistant cancer cells that are responsible for disease recurrence.

The excitement stems in large part from the powerful ability of DUB inhibitors to promote degradation of oncogenic proteins, especially proteins that are challenging to directly target but which are stabilized by DUB family members.