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Furthermore, heterogeneity in host response contributes to the difficulty in interpreting the results of volunteer and epidemiological studies [30], [31], [32], making it challenging to prioritize strains for future genome sequencing, other in-depth analysis or vaccine development.
SNPs within genes which affect the resulting protein or lie in a regulatory region would be obvious candidates for functional studies but, in many complex diseases, the causal SNPs identified to date map to intergenic, non-coding regions and it is more challenging to prioritize these based on likely function (Barton et al., 2008; Thomson et al., 2007; Wellcome Trust Case Control Consortium, 2007).
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"For a business-to-business technology company, and particularly one that's been successful, it's a big challenge to prioritize ease of use".
And IT pros had to sift through all of that data making it a challenge to prioritize the flood of alerts and determining which ones truly required immediate attention.
Therefore, it remains a challenge to prioritize drivers of complex phenotypes, such as disease and drug response, using gene expression data.
Network companies are challenged to find ways to prioritize the energy transition.
An obvious computational challenge is to prioritize candidate causal variants for follow-up functional validation (Gonzalez-Perez et al., 2013).
However, the challenge remains to prioritize SNPs from GWAS for further replication [ 1]; even if one would try to replicate only the top 1% with strongest genetic evidence 5,000-10,000 Sneedneed to be genotyped in replication studies.
Our hope is found in hard-working Americans who spend their days working to house homeless Americans, and the passionate advocates who challenge our leaders to prioritize hurting Americans.
And it's the huge strain of managing two wars and rebuilding the economy (the problems Obama reminds us he inherited)–not to mention revamping our screwed-up health care system (the challenge he chose to prioritize).
He declined to name Skype's partners in the cloud-based initiatives but did say that the company has a "vast number of potential partners," with the challenge being how to prioritize partners.
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