Sentence examples for challenging to established from inspiring English sources

This is a profound point, and challenging to established concepts such as clinical guidelines, evidence-based practice and care pathways.

"It becomes a little challenging to establish special benefits when admission is free".

Clearly, there are several factors that make it challenging to establish bioinformatics programs!

Urban space diversity is seen worldwide as a precondition to overcome boundaries and it is particularly challenging to establish in fast growing emerging cities (Fainstein 2005).

However, due to high mobility, frequent link disconnection, and uneven distribution of vehicles, it becomes quite challenging to establish a robust route for delivering packets.

Yes, it is challenging to establish a regular practice, but it is absolutely required in order to reap any deep and lasting benefits.

A number of individual cancer associated genetic variants have been found recently, but the signaling-level context for these variants has been challenging to establish.

Family-based cohorts are difficult and challenging to establish.

Similarly, it may be challenging to establish a disapproving norm (see [ 49]).

However, it is highly challenging to establish convincing relationships at the superfamily level by means of simple sequence searches.

Such models have proved challenging to establish because synteny with human chromosome Hsa21 is distributed across three mouse chromosomes.