Very little is known about the effects of sensory deprivation on people who rate highly for hallucination proneness, and so it was challenging to accurately estimate effect sizes from existing literature.
However, it is challenging to estimate the effect of woody plant encroachment on carbon because aboveground carbon stocks are very heterogeneous spatially and belowground carbon stocks exhibit complex and variable responses to changing plant cover.
While this offers promise for inhibition, it remains challenging to extrapolate the effect of a genetic defect, established since the time of conception, to a pharmacological intervention of limited duration, usually initiated during adult life.
Although microbiome studies in humans have resulted in an increased awareness regarding the importance of host microbe interactions in health and disease, it remains challenging to determine the effect of isolated host factors on shaping the human microbial flora.
However, it remains challenging to quantify the effects of subscale heterogeneities on dispersion.
Both processes happen simultaneously so it is challenging to disentangle the effects of assimilation change in preferences from those of adaptation adjustment in fertility behavior due to economic opportunities and constraints (Lindstrom and Saucedo 2002).
Yet the absence of baseline data, even within relatively well-replicated studies, makes it challenging to separate management effects from natural variability in populations driven by seascape differences.
Moreover, it is challenging to separate primary effects of an alteration of fibroblast-derived TGF-β from those that are due to altered vascular smooth muscle cell properties.
It is challenging to detect interaction effects among multiple pollutants using standard/generalized linear regression, so it is expected the DSA algorithm proposed for genomic data could be borrowed to address this problem.
This complicated combination of in utero insults means that in many currently available human studies it is challenging to separate the effects of exposure to pre-eclampsia from other in utero insults.
