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This is however a complex and rapidly progressing field and it is challenging to assign in vivo function to intricate sub-phenotypes of T cell.
It is challenging to assign individual roles to the proteins in the complex, since disruption of any component might cause destabilization of shelterin.
Nevertheless, even with well-characterised ecosystems like the human intestinal microbiota it is challenging to assign genus and species level taxonomy to 16S rRNA amplicon reads.
But progression from MCI to AD is not a discrete event; the loss of function necessary to meet criteria for dementia occurs gradually, and it is challenging to assign a specific date to dementia onset.
As with many cellular structures that are below the resolution limit of standard light microscopy, it has been challenging to assign precise locations to proteins at endocytic sites and to determine how their spatial patterns change during the rapid steps of membrane invagination and vesicle scission.
In this study, we used MedEx, the best rule-based medication extraction system in the 2009 i2b2 challenge, to assign medication specific categories into words.
However, this opportunity brings a significant interpretative challenge to assigning function and phenotypic variance to common and rare alleles.
At this time, there remain challenges to assigning taxonomy to eukaryotic tags due to inconsistencies in the public databases.
Given the inconsistencies in species and strain naming and the challenges in assigning to the species level, all predictions were interpreted at a minimum taxonomic rank of genus.
As long as people list that asset — and the I.R.S. does not challenge the value assigned to it before the three-year statute of limitation has expired — then they should be fine, Ms. Connolly said.
He says he's driven by a desire to change the way the world views poverty and to challenge the stereotypes assigned to that term.
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