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Mac points to a patient and shouts: "You're no crazier than the average asshole walking around in the street!" to which Nurse Ratched icily replies: "A very challenging observation".
Like its predecessor, it is a technically challenging observation structure, designed to cater to a smaller number of visitors, and a new landmark for the coastal town – a "vertical pier".
"This was probably the most challenging observation ever tried with the AO system at Keck," said de Pater, referring to use of the laser guide star system next to an object as big and bright as Jupiter.
"It has been the most challenging observation we performed with MAD because we had to track with high accuracy the two moons having different absolute velocities while simultaneously chasing Jupiter, which was moving with respect to them," said Marchetti.
This is a more challenging observation to make, because you have no visual aid to guide the approach towards the Moon's limb.
The changing frequency of HLA alleles in the general population results in a third challenging observation: binding promiscuity between HLA variants and drugs.
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The missing second peak challenged observations of the amount of matter in the universe and threatened theories about how atomic nuclei formed.
However, some identifications arise from low sequence coverage making conclusions about isoforms challenging and observation of posttranslational modifications rare.
Moreover, mice protected from WNV challenge did not develop any clinical signs of illness during the 3-weeks post-challenge observation period.
Limitations to the interpretation of data derived from this typhoid challenge model include logistic, ethical, and financial factors restricting the feasible challenge observation period to 2 weeks.
Clinical acquisition of tolerance was defined by the presence of a negative DBPCFC over a 7-day post-challenge observation period.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com