Sentence examples for challenging indications from inspiring English sources

Although assessing natural selection in human populations is challenging, indications of how natural selection may have moulded human cancer incidence can be assessed by comparing incidences of cancers in wildlife species [ 2].

Recognition of the RTM's ability to support the regeneration of cellular and vascularized soft tissue and the transition to a tissue architecture resembling that specific to the treated site has fueled use by clinicians for new and challenging indications.

9– 11 Treatment of the tear trough is one of the most challenging indications in facial rejuvenation.

The benign clinical behaviour challenges the indication for surgery, which results in loss of renal mass in patients with already compromised renal function.

Furthermore, obtaining tissue from a fresh biopsy is challenging in this indication as the metastatic lesions are often localized to bone [9], [10].

Assessing the comparative effectiveness of many or all available interventions for a clinical indication is challenging.

This leads to the challenge of studying medication effects on endpoints in the observational setting, where issues of confounding by indication are challenging to deal with.

The results from this multi-centre study are promising and appear to challenge the established indications of the use of sliding implants.

To date, the model for insect epithelia being dominated by an apical V-ATPase has not been seriously challenged, so early indications are that broad applicability is likely.

A particular challenge was indications that are more complex and difficult to test, that may require use of new adjuvants.

Moreover, as centers that applied this technique as rescue therapy for refractory hypoxemia recognized its strength and limited technical challenges, the indications for ECMO have recently been extended.