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As is often the case with extremely challenging endeavours where the human stakes are high, the main struggle for me was the emotional and psychological toll the work imposed.
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Cryopreservation of immature oocytes at the GV stage is also the subject for challenging endeavour.
Investigating the early evolution of winged insects (Pterygota) is a thrilling, yet challenging, endeavour.
The endeavour was challenging from the start because of the complicated ambition of including a diversity of actors, potential hotspots, concerns and assessment criteria, but nevertheless the procedure proved its value in both structuring and informing the decision-making process.
[RM, round 2] It was felt that PI needed to be embedded into the culture of organisations; not least by challenging those whose PI endeavour was suggestive of tokenistic practice.
But what's beyond debate is the enduring appeal of the daring criminal challenging the establishment with criminal endeavour.
In short it seems that Mr Wiseman may have become more interested in looking at artistic endeavour than in challenging social ills.
However, this seems a financially challenging and possibly decades-long endeavour.
As one of the few black men in the British judicial system, his early endeavours in the courts were challenging.
They are experiencing the impact of the recent moves to implement the EWTD, an endeavour which is recognised to be challenging.
Challenging the primacy of the Treasury in economic policy-making will be central to this endeavour".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com