The diagnosis of subsurface lesions is challenging, while differentiation between healthy and very early degenerative cartilage is thus virtually impossible [ 9– 11].
Furthermore, inhibition of apoptosis by deleting Bax and Bak promoted ESC self-renewal in cooperation with EMT inhibitors, when challenged with differentiation-inducing miRNAs.
However, it is challenging to guide hPSC differentiation into desired cell lineages due to their varying differentiation ability.
Studies of the mechanisms that regulate human primary trophoblast differentiation are challenging, primarily due to the limited availability of placental tissue during key windows in early trophoblast differentiation and technical difficulties in separating the trophoblast cells from the surrounding decidual cells (49).
Human mesenchymal stem cells (hMSCs) hold great promise for bone regeneration, yet the direction of MSC proliferation and induction of MSC differentiation remain challenging.
While much progress has been made in biomaterial design and application, the rational design of biomaterial cues to direct stem cell behavior and differentiation remains challenging.
In other words, a strong, positive CR is a vital competitive advantage in markets that product differentiation is challenging because it provides leverage for managing consumers (Shamsie 2003).
In the flooded world of marketing and creative companies, differentiation is challenging and near impossible.
Unfortunately, with conventional MRI, recurrences often have similar radiologic characteristics as therapy-related changes such as pseudoprogression (PsP) or radionecrosis, and its mutual differentiation remains challenging [ 2].
Previously, whole genome comparisons have focused on four practically clonal C. pneumoniae human genomes, which make the identification of target genes for strain differentiation quite challenging.
