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A cancer so advanced required, in addition to surgery, a very challenging course of chemotherapy, which was accompanied by debilitating side effects.
With fellow Manxman Randolph Quirk (they were at school together on the island) he devised the so-called "New Syllabus" at UCL, the most elegant and challenging course of undergraduate study ever assembled.
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Have good grades, and have taken challenging courses, and enough of each subject.
We are still challenged, of course, by many of the same concerns of losing continuity, interest, and support.
Post challenge, the course of the antibody response of this group was similar as in group CON.
In addition, UCF's Challenge Course is one of only five in the country to contain a high elements course.
The ruling would be challenged, of course.
It's not that readers shouldn't be challenged, of course.
Ryan had been impressing the judges all season long, winning a record five challenges during the course of the challenge.
Urtasun's new role at Uber isn't without challenges, of course, beyond those of a strictly technical nature.
He had to respond to challenges in the course of things.
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