To challenge the consequence of mTOR inhibition in PCa, HT-sensitive cells were treated with increasing doses of two pharmacological inhibitors of mTOR activity, Rapa and Tem.
However, due to their irregular spatial and temporal distribution exploration and exploitation is challenging and in consequence of the common deep underground location of the aquifer associated with high extraction costs.
Apparent from all key informants was that the migration of nurses is unlikely to abate and retention is challenging as a consequence of global financial, economical, and social pressures.
The diagnosis of cerebrospinal TB is challenging mainly in consequence of the extremely low number of bacilli due to the limited volume of cerebrospinal sample usually available, its subdivision between multiple tests is often self defeating and the highest sensitivity is achieved using the whole sample for the culture in liquid medium only.
However, registering this diversity and understanding its possible consequence is challenging, because variation in chromatin marks has complex properties.
SPM-1 thus uniquely presents structural/sequence similarities to both B1 and B2 subclasses and in consequence is challenging from the perspective of developing broad spectrum MBL inhibitors.
He pushed me and my family through a year of inexplicable, unnecessary suffering, and should face the consequences of challenging his crime, of putting my pain into question, of making us wait so long for justice.
But the tension between celebrating the economic benefits of China's rise and challenging some of its consequences is unlikely to leave the San Francisco arrangements so nearly intact for another 60 years.
Gender disaggregation of data would likely lead to the identification of gaps in humanitarian assistance, subsequently obligating organisations to find ways to fill these gaps, with all its financial and political consequences: not challenging the status quo makes decision-makers' lives considerably easier (Puechguirbal 2010).
There are always consequences for challenging a culture's mythos, but this notion has become nearly impossible to dispute in the days since the economic crash of 2008.
