Morgan Stanley said Altera's near-to-intermediate-term fundamentals will remain challenging, and the potential for additional reductions in forward revenue, margin and earnings estimates remains high.
There are theoretical and practical barriers to improving atherosclerosis-related outcomes in SLE suggesting that this approach will be challenging, and the potential benefit is yet unknown.
Since timely preparation of potency reagents by regulatory authorities is challenging and always a potential bottleneck in influenza vaccine production, it is extremely important that additional approaches for reagent development be available, particularly in the event of an emerging pandemic influenza virus.
All above features differentiated ALA clearly from most other serum-inhibitive nonviral gene carriers, and proved ALA the promising and challenging potential efficient gene vector for practical clinical application.
In many cancers, an astonishing inter- as well as intra-tumor heterogeneity makes it even more challenging to define prognostic signatures and potential therapies.
In his book "The Milosevic Trial," he wrote that the lessons from that case and from Mr. Seselj's trial showed that such proceedings "are simply so complex and challenging that the potential for mischief, disruption, delay and ultimately fairness is too great".
Again, pressure from an authority figure and potential embarrassment made it challenging to take appropriate action.
What makes ad hoc networks interesting and challenging is its potential use in situations where the infrastructure support to run a normal network does not exist.
While the cases were chosen to be clinically relevant and challenging, with many potential student defined learning outcomes, the overall learning objective was to encourage the students to integrate previously learned material and demonstrate clinical relevance.
Achieving this potential will be challenging, and is far from guaranteed, but it is possible.
These complex cell-to-cell interactions and corresponding sequence of events leading to degeneration are difficult to capture and recapitulate by ex vivo models of human disease, making development and testing of potential treatments a particularly challenging and expensive endeavor.
