With local authorities facing major cutbacks, the challenge to target resources effectively is immense.
It has been challenging to target maladaptive generalized memories without affecting adaptive memories.
From a strictly traditional PPC perspective, it is challenging to target a campaign at the persona level, unless you can have granular control across content, video, social, and paid channels.
The couple only switched course after a federal judge invited them to expand their challenge to target the state constitution's ban on same-sex marriage.
Moreover, the ability to potentially inhibit CK1ε using available inhibitors would facilitate downregulation of Wnt/β-catenin signaling in human tumors, which has proven challenging to target pharmacologically.
They discuss a challenge to target the most relevant pathophysiology to treat these symptoms.
It is, therefore, a big challenge to target these treatment-resistant cancer cells that are responsible for disease recurrence.
However, transcription factors such as MYC are challenging to target directly and clinically-effective pharmaceutical agents targeting MYC are not yet available [ 17, 18].
Since CLU is challenging to target with traditional small-molecule inhibitors, the ASO drug OGX-011 (custirsen) was developed to instead inhibit mRNA translation.
Frail and older individuals, unlike groups with a single main diagnosis, are a diffuse group that are challenging to target in a literature search.
