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From a cell source point of view, bone engineers face challenges to isolate and expand cells with the highest potential to form osseous tissue along with harvesting tissue without extensive donor site morbidity.
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Due to lung structural complexity with cellular diversity and slow epithelial cell turnover rates, it is still a challenge to isolate and characterize lung stem/progenitor cells for exploring the lung disease processes and endogenous repair mechanisms.
In the econometric terminology, it will be challenging to isolate or identify the causal effect of s 2, ∂θ 2/∂s 2. If research cannot achieve such identification, then no evidence-based policy on school inputs is feasible.
Given the interest and use of educational technologies and consequent interest by researchers, it is often challenging to isolate the major issues that have been or can be addressed by academic research.
Availability of several stable vanadium oxidation states offers numerous advantages in terms of applications but at the same time it poses great challenge to isolate them in single phase during their synthesis process.
H. cinaedi is extremely challenging to isolate, and therefore needs special laboratory practice.
It is still a great challenge to isolate genes by map-based cloning for the huge genome size of peanut.
Because children are likely to be exposed to multiple environmental chemicals, and because these chemical exposures may be correlated with each other, it is challenging to isolate associations.
Besides, the large morphological variability among CTCs has imposed technical challenge to isolate the whole population, where sophisticated algorithms are required to identify the CTCs.
This bacterium is challenging to isolate and cultivate, as it replicates in short lifespan cells (i.e. polynuclear cells), which rapidly undergo autolysis after sampling.
While it is important to recognize that these two main populations of EVs have distinct biogenesis pathways, it remains technically challenging to isolate their respective pure populations due to their overlapping size distributions and most preparations are therefore heterogeneous [ 3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com