This would challenge the usefulness of ReVS since too wide intervals would make almost any pWCMC to fall within the interval, thus failing to identify those cases where the number of runs is too low to capture relevant placements.
The presence of a bulky fluorescent protein tag, however, may potentially affect significantly the properties of the protein of interest; for AS in particular, its relative small size and, as an intrinsically unfolded protein, its lack of defined secondary structure could challenge the usefulness of fluorescent-protein-based derivatives.
For example, we can challenge the usefulness of a specific belief and generate alternative ideas and solutions that might be better.
Of all the arguments employed by Harris, Dawkins, Hitchens, et al to challenge the usefulness of religion, one is largely overlooked: the way religion feeds our tribal instinct.
Chen et al. (65) also challenged the usefulness of the health transition for policy development.
Work is in progress to perform a prospective clinical study with an appropriate cohort of patients and a long-lasting follow up to challenge the usefulness of the presently proposed biomarker.
Some commentators have challenged the usefulness of the concept of "coping strategies" in the context of HIV and AIDS, as this may imply that people do cope with the situation and will ultimately recover from a transitory change to their livelihoods (Rugalema, 2000).
This paper challenges the theoretical usefulness of essentialist, dichotomous categories such as Western/non-Western or democratic/autocratic and calls for a more nuanced theorizing of immigration policy-making.
This inherent uncertainty challenged the practicability, usefulness, and value of recording a definitive preference.
The current data challenge the clinical usefulness of the MRC-SS in ICU patients early in the course of critical illness.
