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But research that I am currently working on with Roland Rust, Bart Larivière, Lerzan Aksoy, and Luke Williams challenges the relevance of this.
When the new head of the Centre for National Security (Andrew Scott) challenges the relevance of MI6, Bond must covertly enlist the assistance of Moneypenny (Naomie Harris) and Q (Ben Whishaw) to help untangle the web that is SPECTRE.
Moreover, this interpretation also challenges the relevance of motifs as separated functional entities [21].
That the majority of basic and preclinical medical research does not move to clinical trials, let alone lead to substantive improvements in patient health, challenges the relevance of the present translational discovery and development model [ 3, 4].
The effects on the growth of the neurite are inconsistent with the lack of outgrowth phenotype in the loss-of-function analyses, which challenges the relevance of this long-term culture system.
This challenges the relevance of susceptibility in the present day ICU, for if the knowledge of an individual's susceptibility is to be of any use, it is only relevant prior to admission to the ICU.
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I added that it was particularly important to challenge the relevance of "instrumental arguments" about funding; even more so to insist on the "intrinsic importance of values as a key justification" for arts support.
Members of the public were angry, and many openly challenged the relevance of a democracy that could not produce leaders who would improve their lives and provide moral authority.
Judge Owen at one point responded to an objection by prosecutors, apparently to the argumentative flavor of Mr. Keker's remarks; ordered the jury to ignore Mr. Keker's statement at another point that Mr. Quattrone had never been in this kind of trouble before; and later challenged the relevance of Mr. Keker's description of the structure of Credit Suisse First Boston.
At this week's recently concluded (and excellent) ShopTalk conference, several speakers challenged the relevance of omnichannel.
Another response is to challenge the relevance of the conservation principle in this context.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com