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The phrase "challenges of using" is correct and usable in written English.
It can be used when discussing difficulties or obstacles associated with the use of a particular tool, method, or concept.
Example: "The challenges of using new technology in the classroom can hinder effective teaching."
Alternatives: "difficulties in utilizing" or "obstacles to employing".
Exact(60)
The usefulness and challenges of using different plant DNA barcodes were summarized by Hollingsworth et al. (2011).
What are the challenges of using mobiles to protect migrant workers?
Dr. Demetri, of Harvard, acknowledges the challenges of using data self-reported online.
The project aims to test the technological and economic challenges of using giant batteries to provide support to the grid.
These caveats pertain first to the challenges of using survey data to isolate the effects of news media.
"He is expressing the difficulties and the challenges of using social media in an effective way in governing," Mr. Rasiej said in an interview.
Yet the investigation of Mr. Hollander, 37, also highlights the challenges of using lower-level employees to build a case against their boss.
This past year our NHS foundation trust has been beginning to get to grips with the opportunities as well as the challenges of using social media at a corporate as well as clinical level.
One of the main challenges of using cameras and radars for a braking system is how to prevent so-called false positives, in which a car might think an overhead highway sign, for example, is an obstacle to be avoided.
In particular, the challenges of using these materials are discussed.
In addition, the challenges of using flipped classroom approach in K-12 education were identified.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com