In discussion, we reflect on the challenges and value of systematically reviewing this kind of evidence, and note some possible adaptations and developments of our approach.
Methodological challenges include the lack of systematically applied terminology in suicide and risk factor research, the low base rate of suicide, and its complex, multidetermined nature.
Tools to answer this question for the chosen system in vivo are limited, because in living E.coli bacteria it is challenging to systematically modify the width of a cell.
While the wealth of information in these datasets presents an opportunity to leverage these for finding novel drug targets, it remains a challenge to systematically integrate all these highly heterogeneous sources of information to identify novel anti-cancer drug targets.
It became challenging to systematically analyze the acquired knowledge to construct a hierarchical multistage BIN.
Because of the gendered significance of the major concepts of the aesthetic tradition, feminist challenges often systematically deconstruct the concepts of art and aesthetic value reviewed above.
These challenges can cause students to interact with simulations randomly, instead of systematically (de Jong and van Joolingen 1998).
Although this is an attractive proposition, it faces the perpetual challenge of how to systematically train large numbers of attendings and residents in all the steps of cultural awareness, sensitivity, knowledge, attitudes, and skills; and how to simultaneously attend to medical and cultural issues in any given patient encounter.
While he points to them when he discusses the challenges of Academic skepticism, he does not systematically build upon them in refuting skepticism about sense perception, rational knowledge, and knowledge of testimony.
Still another challenge in social justice for public health ethics emerges when the health needs of systematically disadvantaged groups conflict with other dimensions of well-being as well as with considerations of collective efficiency.
