The main challenges of the intervention are loss to follow-up, heterogeneity of the intervention received between patients, and bias in patient recruitment.
37 Despite considerable challenges of effective intervention development for this age group, previous research has found that school-based educational interventions to raise adolescents' cancer awareness are effective, 38 especially among females.
The process varies according to the unique scientific, policy and other challenges of each intervention.
Community and national level strategies to reduce alcohol misuse is an essential, albeit challenging, area of intervention to reduce rates of attempted self-poisoning.
This therapeutic approach was borne out of realisation that virus factors, although conceptually attractive targets because they should, in theory, provide a wide therapeutic index, are challenging points of intervention because of the high mutability of their genomes.
The articles in this special issue illustrate the challenges of implementing interventions in school contexts, as well as the lessons that can be learned from such work.
Having access to recent information, the evaluation did not create new types of tools, but utilized the existing tools to understand the successes and challenges of programme interventions to date.
Campbell and colleagues state that this step addresses issues normally posed by randomized trials, such as sample size, inclusion and exclusion criteria, methods of randomization, as well as the challenges of complex interventions [ 15].
Because of this, the clinical evaluation of Tai Chi poses unique challenges regarding choice of intervention and control groups.
