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Whatever the undoubted challenges of greater Scottish independence, there's a real opportunity here for the north east that will require a fairly important shift in people's thoughts.
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Her hopes that citizens would rise to the challenge of greater freedom were largely fulfilled.
The hapless Mr Hollande has tried to take up Mrs Merkel's challenge of greater political union as the price of more solidarity.
Public health systems across the world are facing the challenge of greater longevity and consequently increasing numbers of age-related adverse health conditions.
There is however the challenge of great heterogeneity in nanoparticles, which will make these discoveries more challenging than for traditional small molecule drug design.
The reduction of CO2 to CO is an ongoing chemical challenge of great interest for the development of renewable and sustainable technologies.
Solving the hydrocarbon phase equilibrium problem is often reported to consume more than 50% of the simulation׳s total CPU time, thus making the speeding up of these calculations a challenge of great interest.
In these studies we were, therefore, never faced with the more common and problematic situation of having to simultaneously quantify unequal amounts of different target sequences, a technical challenge of great general interest.
In the heat-shock environment we provided as a selective challenge, evolution of greater protein thermostability would be beneficial.
Prediction of hydraulic fracture geometry is a difficult challenge and of great importance in oil engineering.
To facilitate the integration of ever higher levels of renewable generation, finding a solution to this challenge is of great interest to utilities and regulators around the globe.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com