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Dissection of transcriptional networks is one of the greatest challenges of functional genomics.
Further discussion of the challenges of functional assessment is given in the section on 'pre-dementia' states.
ONDEX (7), developed with the challenges of functional annotation of T. aestivum genome in mind, combines data integration from various sources and various mining methods, including graph-based analyses, to annotate wheat gene functions according to a wisely chosen set of annotation standards.
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These first cancer genome sequences point to the challenge of functional studies of large numbers of variants of unknown function.
To meet the challenge of functional discrepancy, we propose the combination of existing symbolic composition approaches with machine learning techniques.
We descriptively explain the conceptual and technical integration of our learning recommendation system into an Artificial Intelligence (AI) planning-based technique - a representative of symbolic composition approaches - in order to meet the challenge of functional discrepancy.
An obvious challenge of functional MRI and DTI is inaccurate image-to-patient mapping as well as brain shifts during surgery, which makes adjustments necessary during surgery to maintain accuracy.
Therefore, this paper is focused on the expected challenges of engineering functional safety including the architectures of safety instrumented systems, and the requirements of modularization.
Integration of these gene expression datasets is a promising strategy to alleviate the challenges of protein functional annotation and biological module discovery based on a single gene expression data, which suffers from spurious coexpression.
In contrast to the challenges of detecting functional LKB1 gene dosage described above, two authors have reported that immunohistochemical assessment of LKB1 protein status as a straightforward proxy for both biallelic loss and promoter methylation (Ghaffar et al, 2003; Fenton et al, 2006).
Since the vast majority of noncoding genomic sequence is of unknown function, this increases the challenge of identifying "functional" variants that cause disease.
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