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Despite the challenges, incorporation of biomarkers into clinical trials could better target appropriate patients, and potentially be lifesaving.
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In this paper, challenges to incorporation of intersectionality into population health research are identified or expanded upon.
Major challenges of incorporation of detailed chemistry in flame simulations are induced by the large number of chemical species and the wide range of timescales involved in detailed kinetics.
Additionally, we are finding that each EHR system poses unique challenges to incorporation of genetic information and sending a CDS alert.
The greatest challenge besetting incorporation of miRNA regulation into known gene expression mechanism is the great difficulty in predicting mRNA targets of miRNAs.
However, the imperfect optical properties of conventional PL imaging agents and the challenge in incorporation of therapeutic functions onto them have severely limited their abilities for use in theranostics.
Although the integration of data from different '-omics' techniques is still a challenge, the incorporation of proteomics with systems biology, and the application to study metabolism, is a promising area for future applications in cardiovascular diseases.
But there are challenges that make incorporation (and the listing that is due to follow within two years) imperative.
Future challenges include the incorporation of alternative splicing and polymorphism data into this analysis.
Low- and middle-income countries (LMICs) face increasing challenges due to incorporation, diffusion and utilization of new and modern HTs.
Other extensions that remain challenges include the incorporation of variation in risk by mutation type; extensions to other populations with different risks and/or mutation frequencies; inclusion of data on pathological subtypes (for example, 'basal' breast cancer); tumour histological characteristics; and the inclusion of hormonal, reproductive and lifestyle risk factors.
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