Sentence examples for challenges in the setting of from inspiring English sources

12 PI/r's and cobicistat pose unique challenges in the setting of steroid use, as they inhibit steroid metabolism via CYP3A4 and can drastically increase levels of prednisone and other steroids.

Large thrombus burden remains challenging in the setting of acute myocardial infarct.

Yet these norms are now being challenged in the setting of increased generic manufacturer consolidation and single-source generic drugs.

The aim of this study was to compare the urine and plasma response 60 min after a 50 g oral glucose challenge in the setting of gestational diabetes mellitus (GDM) screening.

That approach has recently been challenged in the setting of critical cardiac illness.

Tumor growth was significantly inhibited in mice immunized against VEGF, VEGFR-2, and Tie2, either before tumor challenge or in the setting of pre-existing disease in murine B16/F10.9 melanoma and MBT-2 bladder tumor models.

This outcome suggests that simulation may serve as an effective foundation for team-based quality improvement, as goals identified by hospital teams were strongly influenced by gaps and challenges that emerged in the setting of simulation scenarios.

Classic randomized clinical trials satisfying contemporary standards are extremely challenging to perform in the setting of established SE.

Predicting which patients with acute circulatory failure will respond to fluid by a significant increase in cardiac output is a daily challenge, in particular in the setting of the intensive care unit (ICU).

Impact on overall survival is challenging to assess in the setting of a heterogeneous and uncontrolled patient population with respect to previous treatments, however, and overall survival was no better among the two responders than among the five non-responders.

In sum, the article's findings suggest that carefully designed mechanisms might be one way to, if not to overcome, at least to facilitate the institutional response of governance challenges in the complex setting of planetary boundaries.