"challenges come up" is correct and usable in written English.
You can use this phrase when referring to difficulties that arise or appear, especially in the context of a task or situation. For example: "Our team was making progress on the project, but then unexpected challenges came up."
But you have to carry that confidence with you constantly without wavering, especially when challenges come up.
The course gave counselors greater confidence, and a network of colleagues to talk to when challenges come up.
Your local hospitals and clinics depend on Medicaid funds in order to serve your community, and that funding needs to be flexible when new health challenges come up from natural disasters, opioid addiction, or diseases like Zika.
However, there was consensus across groups that affordability challenges come up very often with their patients, and it occurs when the issue of noncompliance comes to light, which is often during follow-up visits, readmission, or after an urgent care episode; long after treatment recommendations are made.
"We have tremendous challenges coming up," he said.
"We face some pretty significant challenges coming up," Groh said.
There will be some major 10th Amendment challenges coming up, esp if HCR passes.
The problem was that when challenges came up I felt pretty much alone on them — and the staff was left guessing what was happening.
What kind of challenges came up?
Jamie: What do you see as the biggest challenges coming up to the election for small businesses and the American economy?
As with other chronic diseases cancer survivors have to cope with challenges coming up now and then, and our findings indicate that cancer survivors find ways to deal with consequences of cancer treatment and side effects during the survivorship trajectory.
