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The relationship between ERK, akt mRNA, PI3K and cell vulnerability to βGBP challenge was sustained both in mammary ductal cells forced to mimic an aggressive behaviour and in non-aggressive breast cancer cells undergoing an enforced shift into an aggressive phenotype.
"The challenge is sustaining the victory.
"The challenge is sustaining physical activity in the long-term - so it has to be something that will keep you motivated," says Laventure.
A big challenge is sustaining that effort in the minds of people.
Our central challenge is sustaining the momentum.
The cellular inflammation was characterized by neutrophilia already 24 h after one dsRNA challenge and was sustained by repeated challenges at all time points analysed (Fig. 2C).
The strategic decision by the NTP in 2000 to put the highest priority on capacity building has resulted in impressive progress towards TB control targets, a progress that despite many challenges has been sustained.
Key signings Dusan Tadic and Graziano Pelle have helped Southampton challenge for a Champions League place and Koeman hopes that challenge can be sustained to help him keep his squad together next season.
As described above (Fig 4B), CD3ε°/° recipient mice mounted a CHS response to DNFB only upon CD8 reconstitution, with a mean ear swelling of 330 µm±85 at day 4 after challenge, that was sustained for up to day 9 (Fig 6B).
While appellants' assignment of errors challenge the conclusion of the District Court that the business of the tobacco warehouses was one 'affected with a public interest,' their counsel conceded in the argument at bar that the challenge could not be sustained.
Results: Mice instilled with OVA together with very low doses (≤ 10 3 μg) of LPS displayed modest amounts of Th2 cytokines, with associated airway eosinophilia and AHR after a single challenge, and these responses were sustained after multiple OVA challenges.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com