Sentence examples for challenged to date from inspiring English sources

HIV prevention has been challenged to date by the limited incorporation of social, cultural and economic drivers of HIV [ 34].

However, the discovery of selective STAT3 inhibitors is still challenging to date.

Although effectively targeting KRAS itself has proven challenging to date, targeting the downstream effector MEK1/2, a dual-specific kinase required for activation of ERK1/2, has proven to be effective preclinically in both in vitro and in vivo preclinical studies (Dudley et al, 1995; Sebolt-Leopold et al, 1999; Davies et al, 2007; Daouti et al, 2010).

At his most recent mayor's question time, Johnson was challenged to name the date for his affordable housing target to be met.

Cat Zingano was supposed to offer Rousey her toughest challenge to date, with a 9-0 record and a similar list of challengers conquered.

He said the group's biggest challenge to date was accessing the abandoned underground stations.

Taking Philips to a new frontier is Mr Kleisterlee's toughest challenge to date.

Believe it, this will be Casey's greatest challenge to date as well.

In January, Trudeau's government will face off against its greatest challenge to date: a Trump presidency.

"Dealing with the Conservative-Liberal coalition cuts will present the executive with its biggest policy challenge to date," he said.

He has been on three expeditions to Everest, but Shakespeare's mountainous role is likely to be his greatest challenge to date.