Sentence examples for challenged largely from inspiring English sources

Only one beach, the relatively little-used Wolfe's Pond on Staten Island, received an undesirable rating of "challenged" — largely for the absence of signs warning beachgoers not to swim in areas without lifeguards.

Recently, this traditional view has been challenged, largely since the advent of magnetic resonance imaging (MRI) and its application to the imaging of RA.

90 91 Even the validity of the 'gold standard', jejunal cultures >10 cfu/ml with colonic-type bacteria, has been challenged, largely because this cut-off was established from samples following surgical diversion.

The notion that evolution follows a limited subset of pathways and conforms to rules is not new (Geoffroy Saint-Hilaire, 1818; Vavilov, 1922; Smith et al., 1985), however, its relevance has often been challenged, largely through too frequent invocation of constraints to explain negative data and through lack of experimental insight (Brakefield and Roskam, 2006).

A12 Fertility Clinic Rules Challenged Largely unregulated, fertility clinics have long operated under the assumption that preserving anonymity is best for all parties, but as the stigma of infertility fades both donors and recipients are attacking the secrecy of the process.

Summary: Developing liquid chromatography tandem mass spectrometry (LC-MS/MS) analyses of (bio chemicals is both time consuming and challenging, largely because of the large number of LC and MS instrument parameters that need to be optimized.

Treatment of aggressive glioblastoma brain tumors is challenging, largely due to diffusion barriers preventing efficient drug dosing to tumors.

Arranging experiments to adequately test different factors is challenging, largely because of the difficulties of identifying and testing populations that differ only in the desired variables and not in others (Wiles et al. 2011).

Technical challenges largely concerned system and training issues (Table  1).

Dengue vaccine development has proven challenging, largely because of the four different virus serotypes in circulation.

Quantification of lung fibrosis induced by bleomycin is challenging, largely relying on histology and determination of lung collagen content.