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Speaking in Warsaw, French foreign minister Laurent Fabius told news agencies that the "challenge was considerable".
(The challenge was considerable, since getting lower than one is tough.) After the bevy of new restrictions, abortion today is safer than an injection of penicillin (as it was before the new regulations).
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The renovation challenge is considerable.
Challenge Howarth knows the challenge is considerable.
So Mr. Harris mounts a challenge, and even if we harbor less apocalyptic visions, that challenge is considerable.
The challenge is considerable: over 80% of the world's 50 million people with epilepsy are in the developing world.
The demands of education are unique and the challenge is considerable, we need to not just copy but truly innovate.
That challenge is considerable though, because the gene-editing must be done in far more cells that are harder to get to.
The challenge is considerable: changing the perception of the value and rewards of teaching vis-à-vis other more lucrative fields.
That challenge is considerable, given Chicago's slow start compared with Portland, Ore., and other bike-centered cities, and Mr. Emanuel's initial plan is drawing complaints about an inequitable distribution of the investment.
The therapeutic challenge is considerable: a typical large myocardial infarction that leads to heart failure will kill around 1 billion cardiac myocytes (Laflamme & Murry, 2005), roughly a quarter of the heart's myocytes (Fig 4).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com