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While designing a challenge to verify a building block, the possibility exists that a gold standard cannot be defined or is considered suboptimal as an adequate database, unpublished good quality data or an accessible expert in the field is unavailable.
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Agulla [9] suggests that it can be a real challenge to verify the identity of an individual in an online environment without any physical interaction.
It is a challenge to verify the complex functions of miRNAs.
However, few studies have been assessed in response to MERS-CoV challenge to verify their efficacy, due to a lack of animal models.
Although the rRBD subunit vaccine is a highly potent neutraliser of antibodies and T-cell immune responses, no formulation has been tested on a higher animal model with MERS-CoV challenge to verify its prophylactic efficacy (Gretebeck and Subbarao, 2015).
Each beat-to-beat tracing of intravascular central venous and pulmonary artery pressures was independently assessed by two senior investigators (SJ and JT, blinded for the response to volume challenge) to verify the absence of any spontaneous respiratory activity.
The challenge-based approach creates a metric for comparison between possible solutions to a challenge designed to verify a building block.
GEP students are challenged to verify the sequence assembly of an ∼40-kb region of a Drosophila genome, and/or to annotate the region, identifying elements of interest and creating defendable gene models while working either individually or in teams.
However, it is challenging to verify the consistency of process communications between the design and the implementation.
The figure was widely cited but has been generally challenging to verify.
While it is possible to explore this hypothesis using simulations, it is challenging to verify it experimentally.
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