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As software ever increases in size and complexity, we face the significant challenge to validate the systems surrounding us.
The development of targeted therapies has created a need for robust molecular characterization of cancer and it has become a challenge to validate methods to ensure accuracy in tumor mutation testing.
Since it is a challenge to validate and optimise protective structures against blast loads using full-scale experimental tests, we have to turn our attention towards advanced numerical tools like the finite element method.
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However, it is challenging to validate sensors and data analytics tools in a "live" network.
However, it is extremely challenging to validate these putative markers largely because of the enormous complexity of biological systems, heterogeneity of humans, and/or lack of high-throughput technology [37].
Moreover, the C-R function derived from the U.S. cohort studies would imply an extremely large mortality gradient across the YRD and between different areas of China, which is challenging to validate and interpret.
It would be challenging to validate the effect of O2– on the Cdc25-mediated facilitation of the wt Ras GDP dissociation through monitoring of the GDP dissociation from wt Ras.
While the community knowledge of what constitutes "true protein interactions" in all cellular conditions remain poor, it is still challenging to validate the rest of PPIs that MetaGene data do not cover.
Challenges to validating diagnostic criteria in the absence of clear and identifiable pathophysiological mechanisms are described.
These predictions are challenging to validate experimentally due to the moderate (SQM>) to low (SDL>) peroxisome targeting efficiency of the original Arabidopsis decapeptides, making it difficult to investigate further reductions semi-quantitatively.
However, a major challenge is to validate these data [6], [21], [22], [30].
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