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However, it still remains a challenge to regenerate the functionalized calcified layer.
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A critical challenge to regenerating close mimics of native axonal pathways under chronic neurodegenerative disease or injury conditions is the inability to stimulate, sustain and steer neurite outgrowth over a long distance, until they reach their intended targets.
Despite great efforts in the exploration of therapeutic strategies for treating brain injuries, it is still challenging to regenerate neural tissues and to restore the lost function within an injured brain.
The main challenge was to regenerate the activity of recombinant RC-1 with correct refolding of the peptide by appropriate reformation of the three disulphide bonds (Cys3-Cys16, Cys5-Cys14 and Cys7-Cys12).
This article surveys the current challenges associated with trying to regenerate complex tissues utilizing drug delivery and gives perspectives on the development of translational tissue engineering therapies which promote spatiotemporal cell-signaling cascades to maximize the rate and quality of repair.
An ecologist has challenged RSPB Scotland's plan to regenerate woodlands in Speyside by planting 100,000 trees.
Healing of articular cartilage is still a challenge due to its limited potential to regenerate.
We have a huge need both to build new homes and to regenerate areas of economic challenge and market collapse.
As adult cartilage has very limited potential to regenerate, cartilage repair is challenging.
For instance, Cftr-knockout mice challenged by intratracheal instillation of P. aeruginosa fail to regenerate I-κB alpha, once it is degraded.
This lack of ability to regenerate heart muscle is a major challenge for medicine.
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