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Complexity of antigenic composition, viral genetic heterogeneity and varying epidemiological patterns of hepatitis E in different parts of the world present challenges to the refinement of HEV serological diagnostic assays.
Counterintuitive outcomes like these, besides being practically relevant, challenge and eventually lead to refinement of theories concerning fundamental principles of brain plasticity and learning.
While scattering losses may be reduced by refinement of the plasma etching technique, the absorption losses pose a more difficult challenge to increasing nitride cavity Q-factor.
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However, there are several challenges to realize the dynamic refinement in SPH to achieve improved performance.
Although the identification of small relative risks to humans poses special challenges to scientific research, the refinement of study designs, improvements in methods of exposure assessment, and the use of biomarkers have helped to address the problems (e.g., newer studies on the effects of air pollution, the growth in opportunities to examine gene environment interactions) (Gallo et al. 2011).
The methods are therefore transparent and open to challenge and further refinement.
The world has gone from great leaps to refinements, and the refinements are petering out.
However, this status of EUS has been challenged by refinement of high-resolution magnetic resonance imaging (MRI) techniques that have made accurate T-staging possible.
However, the control of intrinsic point defect is challenging during powder refinement due to the donor-like effect.
Roxy Music's sound also confronts class, challenging notions of refinement.
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