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Due to lung structural complexity with cellular diversity and slow epithelial cell turnover rates, it is still a challenge to isolate and characterize lung stem/progenitor cells for exploring the lung disease processes and endogenous repair mechanisms.
Availability of several stable vanadium oxidation states offers numerous advantages in terms of applications but at the same time it poses great challenge to isolate them in single phase during their synthesis process.
It is still a great challenge to isolate genes by map-based cloning for the huge genome size of peanut.
Besides, the large morphological variability among CTCs has imposed technical challenge to isolate the whole population, where sophisticated algorithms are required to identify the CTCs.
Second, in studies dealing with differential exposures to macronutrients, it is a major challenge to isolate the macronutrient truly responsible for the nutrigenetic effects, particularly for fat and carbohydrates as they tend to be manipulated in such a way that one is compensated by the other.
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In the econometric terminology, it will be challenging to isolate or identify the causal effect of s 2, ∂θ 2/∂s 2. If research cannot achieve such identification, then no evidence-based policy on school inputs is feasible.
Given the interest and use of educational technologies and consequent interest by researchers, it is often challenging to isolate the major issues that have been or can be addressed by academic research.
From a cell source point of view, bone engineers face challenges to isolate and expand cells with the highest potential to form osseous tissue along with harvesting tissue without extensive donor site morbidity.
H. cinaedi is extremely challenging to isolate, and therefore needs special laboratory practice.
Because children are likely to be exposed to multiple environmental chemicals, and because these chemical exposures may be correlated with each other, it is challenging to isolate associations.
This bacterium is challenging to isolate and cultivate, as it replicates in short lifespan cells (i.e. polynuclear cells), which rapidly undergo autolysis after sampling.
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