A major challenge to interrogating these issues in human acute lymphoid leukemia (ALL) is the low proliferative activity of most of the cells, which may be further reduced in cryopreserved samples and difficult to overcome in vitro.
As this system will likely continue to be challenging to interrogate in vitro, progress will be greatly aided by application of high-resolution and real-time cell imaging.
With IYGA we set ourselves the challenge to really interrogate what experiences could be made for mobile devices, exploring the handset and what it affords: location, rendering, connectivity, orientation and audio.
And the plot, as contrived as it is, provides plentiful opportunities to interrogate perversions and challenge the audience with material Hollywood doesn't have the guts to touch.
During his congressional hearing, Trumbo vociferously challenged the right of his inquisitors to interrogate him, prompting a frustrated committee member to yell, "This is typical Communist tactics!" in a futile attempt to get him to shut up.
The micro-analysis of socio-technological disasters offers one way to interrogate the construction and challenge of professional expertise at both the empirical and conceptual levels.
Two women made allegations against Assange five years ago in Stockholm, but no charges have been brought because the prosecutor has been unable to interrogate him after he challenged an extradition order and claimed political asylum in Ecuador's London embassy in June 2012.
Although this approach of setting up a "boundary organisation" was based on a practical response to "bridging the divide" in South Africa, experiences of boundary organisations elsewhere provide a useful way to interrogate the successes and challenges of RENEWAL.
This broad coverage makes it challenging for CTD to accurately design a single-generic query to interrogate the current literature on a routine basis.
