Such a move poses at least two major challenges to identification of relevant evidence: first, search methodologies must be sufficiently robust and rigorous to preserve the credibility of the review, and, second, iterative and intuitive search procedures may render it problematic "to use completely reproducible and transparent search and selection strategies" [ 9].
16 As a referee points out, another challenge to the identification is the possible discrimination according to religion by employers.
A major challenge to the identification of effective disease-modifying therapies arises from an insufficient knowledge about the contribution of multiple pathways to disease pathogenesis.
Many developed countries are facing a major challenge to improve identification of individuals acutely and chronically infected with hepatitis C virus (HCV) infection.
The absence of characteristic plant parts such as leaves and cones in the chopped up market material presents a major challenge to the identification of the species traded.
In addition to this unsolved debate, the complexity of musculoskeletal ageing represents a major challenge to the identification of clinically meaningful biomarkers.
A possible challenge to the identification of equations (1), (2) and (3) is the presence of occupations in which foreigners coming from the same nation tend to cluster (Patel and Vella, 2007).
Clonal evolution and the resulting intratumoral heterogeneity pose a substantial challenge to biomarker identification, personalized cancer therapies and the discovery of underlying driver mutations in cancer.
The instability of the aptamer protein complex in a detergent system used for membrane protein solubilization and cell lysis adds an additional challenge to the identification of an aptamer's target.
This high sequence diversity together with the radically different physical natures of the gating commands, such as pH, temperature, and pressure, have posed a challenge to the identification of unifying models that could explain the mechanisms by which K2Ps act.
