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This variability was a main challenge to handle when planning the design of the evaluation study.
It is always in change, which makes a real challenge to handle the corresponding mathematical models.
In practice, it is still a grand challenge to handle random process in time-variant reliability analysis due to the extremely high computational cost.
The children are wild and sometimes a menacing challenge to handle, yet their love and affection is screamingly beautiful.
Positive test results presented the greatest challenge to handle, because cancer inherently induces fear, anxiety and loss of hope both to self and the family in addition to the possibility that the disease is already advanced.
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Appliances and utensils that are challenging to handle if you have limited manual dexterity.
Equality constraints in them are challenging to handle due to tiny feasible region.
Against this background, the practical applicability of complex models, which might be challenging to handle in real-life contexts, should be considered.
A combination of steel and aluminum is particularly attractive for manufacturing multi-material products but challenging to handle in a pressure welding process.
Thus, EMS physicians are challenged to handle unexpected, unrecognized difficult airways or, to put this the other way round, they must approach every airway as though it could be difficult.
The data generated by a single device may be small, but when the streams of multiple devices are combined, the amount of overall data becomes significantly challenging to handle [ 117 ].
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