Nonetheless, none of them contain annotations about the P. falciparum target(s) involved, making it a challenge to elucidate the mode of action (MoA) of the compounds in the dataset, and hence, making the dataset difficult to interpret.
Oral processing of solid foods is a highly dynamic and complex process; this creates a major challenge to elucidate the role of various components, hierarchical structures and phases on foods' organoleptic properties.
With the limited control over the internal structure of the electrode, it also often poses a significant challenge to elucidate the structure-property relationship between components within the electrode.
Although X-ray crystallography remains the most versatile method to determine the three-dimensional atomic structure of proteins and much progress has been made in model building and refinement techniques, it remains a challenge to elucidate accurately the structure of proteins in medium-resolution crystals.
Ultimately, the strength of imaging genetics and genomics lies in their translational and integrative potential with other research approaches (e.g., nonhuman animal models, psychiatric genetics, pharmacologic challenge) to elucidate brain-based pathways that give rise to the vast individual differences in behavior as well as risk for psychopathology.
It will be an important challenge to elucidate the precise mechanisms and role of caveolin tyrosine phosphorylation in the regulated endocytosis of the insulin receptor by caveolae.
It will be a future challenge to elucidate the pathway that couples microtubule organisation and chemical modification to the timing of the myogenic protein expression programme.
Yet, it remains a challenge to elucidate the exact pathway followed in each specific context (iterative oxidation, oxidation + deamination or even passive DNA demethylation through repelling of DNMT1 [ 102]).
The multi-scale flowing spaces and complex flowing mechanisms of shale gas reservoirs pose challenges to elucidating their production behaviors.
Challenges to elucidating the chemistry of these processes include accessing a variety of well-controlled experimental conditions approaching the point of new particle formation, and having an inexpensive system which can be reproducibly maintained with low levels of contaminants from previous runs and other sources.
