Sentence examples for challenge to construct from inspiring English sources

The railway, about 257 miles long and built through mountainous and malarial jungle, would have been a challenge to construct even with the most modern engineering equipment.

"On the basis of very limited data, it is a real challenge to construct an accurate and robust model of hedge-fund returns," Brown said.

Asked whether he now faces a challenge to construct a shadow cabinet without several senior figures who have said they will not join, the new Labour leader said: "There's going to be an inclusive, open process.

It is also a great challenge to construct and validate the illustrative descriptors of a language framework (Zhu 2015).

CAVEs are a challenge to construct because their hundreds of constituent components are mostly adapted off-the-shelf technologies that were designed for other uses.

Given that it is a major challenge to construct an isochronal foliation we use non-isochronal phase-amplitude coordinates as a practical method for obtaining a more accurate description of neural systems.

It is challenging to construct a reliable numerical algorithm to accurately capture the non-equilibrium physical effect in different regimes.

Robust, programmatically accessible biomedical information services that syntactically and semantically interoperate with other resources are challenging to construct.

However, even if sufficient data are available, it is challenging to construct a model of cell signalling to explain the data and make accurate predictions.

As the experimental structures of KCNQ2 and its complexes with other ligands have not been determined, it is challenging to construct a structural model for the ztz240-KCNQ2 interaction.

Systems approaches have long been used in pharmacology to understand drug action at the organ and organismal levels using experimental and computational approaches It would be great challenges to construct a computational model of a multi-level for understanding drug action and discovering drug with the lack of multi-level data.